Genetic engineering is a modern and very promising sphere of biotechnology. It unites the experience gained from biology, genetics, virology, chemistry, and other sciences to alter genotypes.  With artificial modifications and manipulations made to DNA and RNA using technology, organisms are given the desirable characteristics. This could cure numerous diseases.

In this respect, the stocks of companies that undertake research and development initiatives in this sphere are popular among investors. Today we will present one of these companies. Prime Medicine, Inc. placed its shares on the NASDAQ on 20 October 2022 under the ticker PRME.

Prime Medicine logo
Prime Medicine logo

What we know about Prime Medicine

Prime Medicine Inc. is a biotech company that develops a new class of differentiated genetic drugs for curing complex diseases. It works on implementing the Prime Editing technology of gene editing.

Prime Medicine states that Prime Editing can potentially correct about 90% of all known malignant genetic mutations in many human organ cells. Drugs based on this technology could help patients if approved by the regulator.

Prime Medicine's business
Prime Medicine's business

According to Prime Editing developers, the next-generation technology could be effective against the following diseases:

  • Chronic granulomatous disease that affects the human immune system
  • Wilson’s Disease, which is a severe hereditary disease affecting the central neural system, liver, and other organs
  • Retinitis pigmentosa, a hereditary degenerative eye disease
  • Friedreich’s Ataxia, which is an autosomal recessive neurodegenerative disease that affects the central and peripheral neural systems, heart, and other organs
  • Myotonic dystrophy, a hereditary type of muscular dystrophy
Prime Medicine's business
Prime Medicine's business

Together with Myeloid Therapeutics, Prime Medicine develops the LINE-1 technology that can enhance Prime Editing methods, which could be effective against many more diseases, not only genetic ones.

Prime Medicine's business
Prime Medicine's business

As estimated on 30 April 2021, the investments the company attracted amounted to $315 million.

Target market prospects of Prime Medicine

The issuer assessed the potential of its target market independently. According to Prime Medicine, the average course of treatment per patient is roughly $2 million. Based on this number, the company estimates its target market at $57 billion.

The main competitors are:

  • Third Harmonic Bio Inc.
  • Rhythm Pharmaceuticals Inc.
  • Merck & Co. Inc.
  • Vertex Pharmaceuticals Incorporated
  • Biogen Inc.

Prime Medicine’s financial performance

There were no earnings or profits in the S-1 financial statistics form. However, there were serious expenses on scientific research and administration.

Prime Medicine’s net loss in 2021, compared to 2020, skyrocketed 4749.5% to $165.4 million. But it is worth noting that the net loss in the period from January to June 2022, compared to the statistics of last year, dropped by 38.2% to $53,2 million.

Financial performance of Prime Medicine
Financial performance of Prime Medicine

The cash reserves of the company after the IPO are estimated at $216 million. Management believes this will be enough until 2025. The long-term liabilities of the company amount to $46 million.

Strengths and weaknesses of Prime Medicine


  • Promising target market
  • Expansion into the worldwide market
  • Cutting-edge promising product
  • Unique technology of development


  • Strong competition
  • No net profit or earnings

What we know about Prime Medicine IPO

The underwriters of the IPO of Prime Medicine, Inc. are Morgan Stanley & Co. LLC, Jefferies LLC, Goldman Sachs & Co. LLC, and J.P. Morgan Securities LLC. The issuer sold 10.29 million standard shares at an average price of $17 each.

Gross earnings from selling the shares amounted to roughly $175 million, minus standard options sold by underwriters. The current market capitalisation is $1.43 billion. Note that the IPO of Prime Medicine, Inc. is the largest biotech IPO carried out this year.

As the company does not generate any profit, the potential capitalisation cannot be estimated by classical multipliers. At the last round of financing, the company was assessed at $1.7 billion.

Participation in this IPO might be considered an investment with high risks, which is not suitable for all investors. When this article was being prepared, the shares of the issuer were still available at a price lower than the one listed for the IPO.

Material is prepared by

Vadim has a higher education in finance and economics. He started becoming familiar with financial markets in 2012, and now specialises in analysing IPOs and portfolio investments.